AustralieFrV1, Main, Exploration, bibRecord, 00D855

Exclusion of close linkage of bipolar disorder to the dopamine D3 receptor gene in nine Australian pedigrees

Identifieur interne : 00D855 ( Main/Exploration ); précédent : 00D854; suivant : 00D856

Exclusion of close linkage of bipolar disorder to the dopamine D3 receptor gene in nine Australian pedigrees

Auteurs : Philip Mitchell [Australie] ; Brent Waters [Australie] ; Christina Vivero [Australie] ; Fie Le [Australie] ; Jennifer Donald [Australie] ; Michele Tully [Australie] ; Karen Campedelli [Australie] ; Lars Lannfelt [Suède] ; Pierre Sokoloff [France] ; John Shine [Australie] ; Lisa Selbie [Australie]

Source :

Journal of Affective Disorders [ 0165-0327 ] ; 1993.

RBID : ISTEX:CC7F711D47F813C66F6BEB2CA1EDA73EC831D427

Descripteurs français

Pascal (Inist)
- Carte génétique, Chromosome A3, Déterminisme génétique, Etude familiale, Homme, Linkage, Récepteur dopaminergique D3, Trouble bipolaire, Trouble humeur.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- A3-Chromosome, Affective, Affective disorder, Affective disorders, Allele, Autosomal, Bipolar, Bipolar affective disorder, Bipolar disorder, D3 Dopamine receptor, Disorder, Dopamine, Drd3, Drd3 gene, Family study, Gene, Genet, Genetic mapping, Genome, Gershon, Giro, Human, Inheritance, Large number, Linkage, Linkage analyses, Linkage analysis, Linkage studies, Manic depression, Maximum penetrance, Mood disorder, Pedigree, Penetrance, Polymorphism, Receptor, Receptor gene, Receptor genes, Recessive, Recombination, Recombination fraction, Sokoloff, Sporadic rate, Sporadic rates, Theta, Wide range.
Teeft :
- Affective, Affective disorder, Affective disorders, Allele, Autosomal, Bipolar, Bipolar affective disorder, Bipolar disorder, Disorder, Dopamine, Drd3, Drd3 gene, Gene, Genet, Genome, Gershon, Giro, Large number, Linkage, Linkage analyses, Linkage analysis, Linkage studies, Manic depression, Maximum penetrance, Pedigree, Penetrance, Polymorphism, Receptor, Receptor gene, Receptor genes, Recessive, Recombination, Recombination fraction, Sokoloff, Sporadic rate, Sporadic rates, Theta, Wide range.

Abstract

Abstract: The recently cloned dopamine D3 receptor (DRD3) gene is of potential relevance to the aetiology of bipolar disorder because of an almost exclusive expression in limbic tissue, the region of the brain putatively responsible for control of emotion. We therefore aimed to determine whether bipolar disorder in nine pedigrees (with 171 members) was linked to this receptor gene, which has been mapped to chromosomal region 3q 13.3. Linkage of bipolar disorder and recurrent depression to the DRD3 gene was tested using a series of autosomal dominant and recessive models with varying penetrance levels. Additionally, linkage was examined using a series of levels of definitions of affective illness (ranging from bipolar I alone to all affective disorders). Close linkage to the DRD3 gene was strongly excluded using each model and definition, and these conclusions persisted when a wide range of rates of ‘sporadic’ (non-genetic) presentations of illness were incorporated in the analysis.

Url:

https://api.istex.fr/document/CC7F711D47F813C66F6BEB2CA1EDA73EC831D427/fulltext/pdf

DOI: 10.1016/0165-0327(93)90045-L

Affiliations:

Le document en format XML

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<term>Affective disorders</term>
<term>Allele</term>
<term>Autosomal</term>
<term>Bipolar</term>
<term>Bipolar affective disorder</term>
<term>Bipolar disorder</term>
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<term>Linkage analyses</term>
<term>Linkage analysis</term>
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<front><div type="abstract" xml:lang="en">Abstract: The recently cloned dopamine D3 receptor (DRD3) gene is of potential relevance to the aetiology of bipolar disorder because of an almost exclusive expression in limbic tissue, the region of the brain putatively responsible for control of emotion. We therefore aimed to determine whether bipolar disorder in nine pedigrees (with 171 members) was linked to this receptor gene, which has been mapped to chromosomal region 3q 13.3. Linkage of bipolar disorder and recurrent depression to the DRD3 gene was tested using a series of autosomal dominant and recessive models with varying penetrance levels. Additionally, linkage was examined using a series of levels of definitions of affective illness (ranging from bipolar I alone to all affective disorders). Close linkage to the DRD3 gene was strongly excluded using each model and definition, and these conclusions persisted when a wide range of rates of ‘sporadic’ (non-genetic) presentations of illness were incorporated in the analysis.</div>
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Serveur d'exploration sur les relations entre la France et l'Australie

Exclusion of close linkage of bipolar disorder to the dopamine D3 receptor gene in nine Australian pedigrees

Exclusion of close linkage of bipolar disorder to the dopamine D3 receptor gene in nine Australian pedigrees

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur les relations entre la France et l'Australie
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